Which condition is characterized by personality changes and reduced verbal output early in the disease?

Pick's disease, also known as frontotemporal dementia, is characterized by significant personality changes and a reduction in verbal output during the early stages of the disease. This condition is associated with the degeneration of the frontal and temporal lobes of the brain, which play critical roles in personality, behavior, and language. Individuals with Pick's disease often exhibit changes in social conduct, emotional responses, and a decline in the ability to communicate effectively, sometimes leading to decreased speech fluency.

In contrast, Huntington's disease typically involves motor disturbances and cognitive decline but may not present with prominent personality changes as early as Pick's disease. Alzheimer's disease generally features memory loss as the primary early symptom, while changes in personality and reduced verbal output develop later in the progression. Parkinson’s disease also presents with motor symptoms that can affect speech but does not primarily feature early personality changes or reduced verbal output in the same manner as Pick’s disease does. Thus, the distinguishing characteristics of Pick's disease make it the correct answer in this context.